Roscales García, SilviaGarcía Csaky, Aurelio2025-11-112025-11-112025-08-27Silvia Roscales, Aurelio G. Csáky, Advanced Synthesis & Catalysis 2025, 367, e70084. https://doi.org/10.1002/adsc.7008410.1002/adsc.70084https://hdl.handle.net/20.500.14352/125943Dearomatization is a powerful strategy for constructing complex carbocycles and heterocycles, though it typically relies on harsh conditions due to aromatic stability. Herein, a visible-light-driven photocatalytic dearomatization strategy for electron-poor imidazo[1,2-a]pyridines is reported, addressing a key limitation of current methods, which predominantly target electron-rich aromatic systems. Using α-keto acids as acyl radical precursors, this mild method enables the efficient synthesis of structurally diverse and functionalized imidazole derivatives, a privileged scaffold in pharmaceuticals and advanced materials. Some of the synthesized imidazoles display noteworthy photophysical properties. Some of the synthesized imidazoles show dual fluorescence from deep violet to greenish-cyan, highlighting potential as innovative fluorescent probes. This work expands the scope of dearomatization and provides a valuable tool for accessing new chemical space in drug discovery and materials science.engjournal articlehttps://advanced.onlinelibrary.wiley.com/doi/10.1002/adsc.70084open access547C─C couplingDearomatizationFluorescenceKetonesPhotocatalysisQuímica orgánica (Química)2306 Química Orgánica