Puente Maestu, LuisLópez, EloísaSayas Catalán, JavierAlday, EnriquePlanas, AntonioParise, Diego J.Martínez Borja, MarcosGarutti Martínez, Ignacio2024-02-052024-02-052021-02-01Puente-Maestú L, López E, Sayas J, Alday E, Planas A, Parise DJ, Martínez-Borja M, Garutti I; PI12/02734 study group. The effect of immediate postoperative Boussignac CPAP on adverse pulmonary events after thoracic surgery: A multicentre, randomised controlled trial. Eur J Anaesthesiol. 2021 Feb 1;38(2):164-170. doi: 10.1097/EJA.0000000000001369. PMID: 33186306.0265-021510.1097/EJA.0000000000001369https://hdl.handle.net/20.500.14352/98620Abstract Background: The effectiveness of prophylactic continuous positive pressure ventilation (CPAP) after thoracic surgery is not clearly established. Objective: The aim of this study was to assess the effectiveness of CPAP immediately after lung resection either by thoracotomy or thoracoscopy in preventing atelectasis and pneumonia. Design: A multicentre, randomised, controlled, open-label trial. Settings: Four large University hospitals at Madrid (Spain) from March 2014 to December 2016. Patients: Immunocompetent patients scheduled for lung resection, without previous diagnosis of sleep-apnoea syndrome or severe bullous emphysema. Four hundred and sixty-four patients were assessed, 426 were randomised and 422 were finally analysed. Intervention: Six hours of continuous CPAP through a Boussignac system versus standard care. Main outcome measures: Primary outcome: incidence of the composite endpoint 'atelectasis + pneumonia'. Secondary outcome: incidence of the composite endpoint 'persistent air leak + pneumothorax'. Results: The primary outcome occurred in 35 patients (17%) of the CPAP group and in 58 (27%) of the control group [adjusted relative risk (ARR) 0.53, 95% CI 0.30 to 0.93]. The secondary outcome occurred in 33 patients (16%) of the CPAP group and in 29 (14%) of the control group [ARR 0.92, 95% CI 0.51 to 1.65]. Conclusion: Prophylactic CPAP decreased the incidence of the composite endpoint 'postoperative atelectasis + pneumonia' without increasing the incidence of the endpoint 'postoperative persistent air leaks + pneumothorax'.engjournal articlehttps://journals.lww.com/ejanaesthesiology/fulltext/2021/02000/the_effect_of_immediate_postoperative_boussignac.8.aspx33186306https://pubmed.ncbi.nlm.nih.gov/33186306/restricted access616.24Ciencias Biomédicas32 Ciencias Médicas