Wijnker, ErikHarashima, HirofumiMüller, KatjaParra Núñez, PabloBastiaan de Snoo, C.Van de Belt, JoséDissmeyer, NicoBayer, MartinPradillo Orellana, MónicaSchnittger, Arp2023-06-172023-06-172019-060027-8424, ESSN: 1091-649010.1073/pnas.1820753116https://hdl.handle.net/20.500.14352/13834Little is known how patterns of cross-over (CO) numbers and distribution during meiosis are established. Here, we reveal that cyclin-dependent kinase A;1 (CDKA;1), the homolog of human Cdk1 and Cdk2, is a major regulator of meiotic recombination in Arabidopsis. Arabidopsis plants with reduced CDKA;1 activity experienced a decrease of class I COs, especially lowering recombination rates in centromere-proximal regions. Interestingly, this reduction of type I CO did not affect CO assurance, a mechanism by which each chromosome receives at least one CO, resulting in all chromosomes exhibiting similar genetic lengths in weak loss-of-function cdka;1 mutants. Conversely, an increase of CDKA;1 activity resulted in elevated recombination frequencies. Thus, modulation of CDKA;1 kinase activity affects the number and placement of COs along the chromosome axis in a dose-dependent manner.engAtribución-NoComercial-SinDerivadas 3.0 Españahttps://creativecommons.org/licenses/by-nc-nd/3.0/es/journal articlehttps://doi.org/10.1073/pnas.1820753116open access581.15MeiosisCyclin-dependent kinaseCross-over interferenceClass I crossoversMeiotic recombinationBotánica (Biología)Genética2417.03 Botánica General2409 Genética