Lozano Picazo, PalomaCastro Domínguez, CristinaBruno, Augusto LuisBaeza García, AlejandroMartínez, Adelia S.López, Patricia A.Castro María, ÁngelaLakhal, YassminMontero, ElenaColchero Paetz, LuisGonzález Nieto, DanielRojo, Francisco JavierPanetsos Petrova, FivosRamos Gómez, MilagrosDaza, RafaelGañán Calvo, Alfonso M.Elices Calafat, ManuelGuinea, Gustavo VíctorPérez Rigueiro, José2023-07-142023-07-142022-06-281420-304910.3390/molecules27134146https://hdl.handle.net/20.500.14352/87230Received: 26 May 2022 / Revised: 24 June 2022 / Accepted: 25 June 2022 / Published: 28 June 2022High-performance regenerated silkworm (Bombyx mori) silk fibers can be produced efficiently through the straining flow spinning (SFS) technique. In addition to an enhanced biocompatibility that results from the removal of contaminants during the processing of the material, regenerated silk fibers may be functionalized conveniently by using a range of different strategies. In this work, the possibility of implementing various functionalization techniques is explored, including the production of fluorescent fibers that may be tracked when implanted, the combination of the fibers with enzymes to yield fibers with catalytic properties, and the functionalization of the fibers with cell-adhesion motifs to modulate the adherence of different cell lineages to the material. When considered globally, all these techniques are a strong indication not only of the high versatility offered by the functionalization of regenerated fibers in terms of the different chemistries that can be employed, but also on the wide range of applications that can be covered with these functionalized fibers.engAttribution 4.0 Internationaljournal articlehttps://doi.org/10.3390/molecules27134146https://www.mdpi.com/1420-3049/27/13/4146open access539.19543.426Silk; Functionalization; Fluorophore; Streptavidin; Biotin; Click chemistryQuímica orgánica (Química)2306.90 Química de Productos Naturales Orgánicos2306.18 Estructuras de las Moléculas Orgánicas