Díaz Gómez, SergioSankaridurg, PadmajaLópez Garrido, José ABurgos Martínez, MercedesCarballo Álvarez, Jesús2026-02-242026-02-242025-09Díaz-Gómez S, Sankaridurg P, López-Garrido JA, Burgos-Martínez M, Carballo-Álvarez J. Three-year myopia management efficacy of extended depth of focus soft contact lenses (MYLO) in Caucasian children. Ophthalmic Physiol Opt. 2025 Sep;45(6):1512-1524. doi: 10.1111/opo.13549. Epub 2025 Jun 30. PMID: 40586420; PMCID: PMC12357222.10.1111/opo.13549https://hdl.handle.net/20.500.14352/133094Purpose: To evaluate the progression of myopia as assessed by changes in axial length (AL) and spherical equivalent (SE) in Caucasian children wearing extended depth of focus soft contact lenses (CL) compared with distance single-vision spectacles after 3 years. Methods: A total of 96 progressing (at least -0.75 D increase in the previous 12 months) myopic children (aged 6-13 years) with SE ranging from -0.75 to -10.00 D were recruited. Forty-five children were fitted with CL (MYLO), whereas 51 wore spectacles. Cycloplegic refraction was measured with an auto-refractometer and AL with the Zeiss IOLMaster-700 at 6-month intervals. Subjective responses of CL wear were determined using a questionnaire on a scale of 1 (very poor) to 10 (excellent). High-contrast visual acuity (HCVA) was also evaluated. Results: A total of 43 and 41 children achieved 3 years of wear with CL and spectacles, respectively. Mean change in SE and AL was -0.90 ± 0.36 D and 0.55 ± 0.04 mm in the CL group and -1.64 ± 0.26 D and 0.97 ± 0.03 mm in the spectacle group, respectively (all p < 0.001). The cumulative absolute reduction in axial elongation was 0.42 mm. The difference in SE change was 0.74 D. While 90% of the children wearing CL had an AL increase of ≤0.60 mm, 96% of the spectacle group increased by at least 0.91 mm. Indeed, 50% of the CL group showed myopia progression of at least 0.75 D, whereas all the spectacle group progressed by at least 0.75 D. Subjective responses indicated a mean value ≥9. There was a reduction in HCVA of half a logMAR line with CL compared to spectacles (p < 0.001). Conclusions: Three years of wear with MYLO CL resulted in clinically significant slower myopia progression compared to the SV spectacle group.engAttribution-ShareAlike 4.0 Internationalhttp://creativecommons.org/licenses/by-sa/4.0/journal articlehttps://doi.org/10.1111/opo.1354940586420open access617.7-089CaucasianContact lensesCumulative absolute reduction in axial elongationExtended depth of focusMyopiaCiencias Biomédicas32 Ciencias Médicas