Correlations between corneal and optic nerve head variables in healthy subjects and patients with primary open angle glaucoma

Sáenz Francés, FedericoJañez Escalada, LuisBorrego Sanz, LaraBerrozpe Villabona, ClaraMartínez De La Casa Fernández-Borrella, José MaríaMorales Fernández, LauraGarcía Sánchez, JuliánSantos Bueso, Enrique MiguelGarcía Feijoo, Julián2023-06-182023-06-182015-12-18Sáenz Francés, F., Jañez Escalada, L., Borrego Sanz, L. et al. «Correlations between Corneal and Optic Nerve Head Variables in Healthy Subjects and Patients with Primary Open Angle Glaucoma». International Journal of Ophthalmology, vol. 8, n.o 6, noviembre de 2015, pp. 1156-61. www.ijo.cn, https://doi.org/10.3980/j.issn.2222-3959.2015.06.14.2222-395910.3980/j.issn.2222-3959.2015.06.14https://hdl.handle.net/20.500.14352/23131En O.A. en la web del editor.AIM: To correlate corneal variables (determined using the Pentacam) with optic nerve head (ONH) variables determined using the Heidelberg retina tomograph (HRT) in healthy subjects and patients diagnosed with primary open angle glaucoma (POAG). METHODS: Measurements were made in 75 healthy eyes and 73 eyes with POAG and correlations examined through Pearson correlation coefficients between the two sets of variables in the two subject groups. The corneal variables determined were corneal volume (CVol), central corneal thickness (CCT), overall corneal thickness (OvCT), the mean thickness of a circular zone centered at the corneal apex of 1 mm radius (zone I) and the mean thickness of several concentric rings, also centered at the apex until the limbus, each of 1 mm width (zones II to VI respectively). The ONH variables were determined using the HRT. RESULTS: The following pairs of variables were correlated in the control group: CCT-disc area (DAr) (-0.48; P<0.0001), Zone I-DAr (-0.503; P<0.0001) and Zone II-DAr (-0.443; P<0.0001); and in the POAG group: CCT-cup-to-disc area ratio (CDRa) (-0.402; P<0.0001), Zone I-CDRa (-0.418; P<0.0001), Zone II-CDRa (-0.405; P=0.006), Zone I-cup shape measure (CSM) (-0.415; P=0.002), Zone II-CSM (-0.405; P=0.001), Zone IV-height variation contour (HVC) (0.378; P=0.002); Zone V-HVC (0.388, P<0.0001). CONCLUSION: AS-OCT-derived lens thickness measurement is valid and comparable to the results obtained by A-scan US. It can be used as a reliable noncontact method for measuring lens thickness in adults with or without significant cataract.engAtribución-NoComercial-SinDerivadas 3.0 Españahttps://creativecommons.org/licenses/by-nc-nd/3.0/es/Correlations between corneal and optic nerve head variables in healthy subjects and patients with primary open angle glaucomajournal articlehttps://dx.doi.org/10.3980%2Fj.issn.2222-3959.2015.06.14https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651881/open access617.7-007.681617.749617.73-073GlaucomaOptic nerve headCorneal thicknessDiagnóstico por imagen y medicina nuclearOftalmología3204.01 Medicina Nuclear3201.09 Oftalmología