Martínez Carmona, MarinaLozano Borregón, DanielBaeza, AlejandroColilla Nieto, MontserratVallet Regí, María Dulce Nombre2023-06-172023-06-172017-09-192040-337210.1039/c7nr05050jhttps://hdl.handle.net/20.500.14352/18195A novel singlet-oxygen sensitive drug delivery nanocarrier able to release their cargo after exposure to visible (Vis) light of a common lamp is presented. This nanodevice is based on mesoporous silica nanoparticles (MSN) decorated with porphyrin-caps grafted via reactive oxygen species (ROS)-cleavable linkages. In presence of Vis light the porphyrinnanocaps produce singlet oxygen molecules that break the sensitive-linker, which triggers pore uncapping and therefore allows the release of the entrapped cargo (topotecan, TOP). This new system takes advantage of thE non-toxicity and greater penetration capacity of Vis radiation and a double antitumor effect due to the drug release and the ROS production. In vitro tests with HOS osteosarcoma cancer cells reveal that TOP is able to be released in a controlled fashion inside the tumor cells. This research work constitutes a proof of concept that opens up promising expectations in the seeking for new alternatives for the treatment of cancer.engjournal articlehttp://www.rsc.org/open access546615.46Cancer treatmentMesoporous silica nanoparticles (MSN)Singlet oxygen moleculesMaterialesQuímica inorgánica (Química)3312 Tecnología de Materiales2303 Química Inorgánica