López Cuenca, InésGarcía Martín, Elena SalobrarGil Salgado, InésSánchez Puebla, LídiaElvira Hurtado, LorenaFernández Albarral, José AntonioRamírez Toraño, FedericoBarabash, AnaFrutos Lucas, Jaisalmer deSalazar Corral, Juan JoséRamirez Sebastian, Jose ManuelRamírez Sebastián, Ana IsabelHoz Montañana, María Rosa de2023-06-222023-06-222022-05-232075-442610.3390/jpm12050847https://hdl.handle.net/20.500.14352/71694Received: 19 April 2022 / Revised: 17 May 2022 / Accepted: 19 May 2022 / Published: 23 May 2022Having a family history (FH+) of Alzheimer’s disease (AD) and being a carrier of at least one ɛ4 allele of the ApoE gene are two of the main risk factors for the development of AD. AD and age-related macular degeneration (AMD) share one of the main risk factors, such as age, and characteristics including the presence of deposits (Aβ plaques in AD and drusen in AMD); however, the role of apolipoprotein E isoforms in both pathologies is controversial. We analyzed and characterized retinal drusen by optical coherence tomography (OCT) in subjects, classifying them by their AD FH (FH- or FH+) and their allelic characterization of ApoE ɛ4 (ApoE ɛ4- or ApoE ɛ4+) and considering cardiovascular risk factors (hypercholesterolemia, hypertension, and diabetes mellitus). In addition, we analyzed the choroidal thickness by OCT and the area of the foveal avascular zone with OCTA. We did not find a relationship between a family history of AD or any of the ApoE isoforms and the presence or absence of drusen. Subjects with drusen show choroidal thinning compared to patients without drusen, and thinning could trigger changes in choroidal perfusion that may give rise to the deposits that generate drusenengAtribución 3.0 Españajournal articlehttps://doi.org/10.3390/jpm12050847https://www.mdpi.com/2075-4426/12/5/847open access616.894-053.9611.843.112:616.894-053.9611.843.112:616-073.75Alzheimer’s diseaseApoE ɛ4family historyhard drusenOCTretinaAMDhypercholesterolemiahypertensiondiabetes mellituschoroidNeurociencias (Medicina)OftalmologíaAnatomía ocularTécnicas de la imagen2490 Neurociencias3201.09 Oftalmología