Miguel Díez, Javier DeGutiérrez Albaladejo, NataliaCaballero Segura, Francisco J.López De Andrés, Ana IsabelZamoranovLeon, José J.Hernández Barrera, ValentínJiménez García, RodrigoCarabantes Alarcón, DavidOmaña Palanco, RicardoCuadrado Corrales, María NatividadElsevier2024-02-062024-02-062024-01de-Miguel-Diez J, Gutierrez-Albaladejo N, Caballero-Segura FJ, Lopez-de-Andres A, Jimenez-Garcia R, Zamorano-Leon JJ, Carabantes-Alarcon D, Omaña-Palanco R, Hernández-Barrera V, Cuadrado-Corrales N. Trends and sex differences in atrial fibrillation among patients hospitalized due to asthma: Insights from a nationwide population-based discharge database in Spain, 2016-2021. Respir Med. 2024 Jan;221:107508. doi: 10.1016/j.rmed.2023.107508. Epub 2023 Dec 22. PMID: 38135195.0954-611110.1016/j.rmed.2023.107508https://hdl.handle.net/20.500.14352/99689Aims: To analyze changes in the prevalence of atrial fibrillation (AF) in patients hospitalized due to asthma; to compare hospital outcomes in asthma patients with and without AF, assessing sex differences; to identify variables associated with the presence of AF; and to analyze the factors associated with in-hospital mortality (IHM) among asthma patients with AF. Methods: We used data from the Registry of Specialized Care Activity-Basic Minimum Data Set to select all patients aged ≥40 years with an asthma diagnosis in Spain, from 2016 to 2021. We stratified the study population according to the presence of AF and sex. Results: We identified 65,233 hospitalizations that met the inclusion criteria (14.85 % with AF). The prevalence of AF significantly increased over time, with the male sex being a protective factor for its presentation. IHM were significantly higher in patients with AF. Older age, being a woman, congestive heart failure, renal disease, obstructive sleep apnea, hypertension, and hyperthyroidism were associated with the presence of AF. Advanced age and the presence of cancer and COVID-19 were factors associated with a higher IHM, as well as admission to an intensive care unit and the use of invasive mechanical ventilation. There were no association of sex with the IHM.Conclusions: AF is highly prevalent among subjects hospitalized due to asthma, with this prevalence having increased significantly in Spain over time. The presence of AF in patients with asthma was associated significantly with a higher LOHS and IHM. Sex was not associated with IHM in these patients.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal articlehttps//doi.org/10.1016/j.rmed.2023.107508https://www.resmedjournal.com/article/S0954-6111(23)00396-7/fulltextopen access61AsthmaAtrial fibrillationHospital admissionsIn-hospital mortalityPrevalenceSex-differencesCiencias Biomédicas32 Ciencias Médicas