Montero Calle, AnaGarranzo Asensio, MaríaMoreno Casbas, Maria TeresaCampuzano Ruiz, SusanaBarderas Manchado, Rodrigo2025-09-152025-09-152024-08-21Montero-Calle A, Garranzo-Asensio M, Moreno-Casbas MT, Campuzano S and Barderas R (2024) Autoantibodies in cancer: a systematic review of their clinical role in the most prevalent cancers. Front. Immunol. 15:1455602. doi: 10.3389/fimmu.2024.145560210.3389/fimmu.2024.1455602https://hdl.handle.net/20.500.14352/123956Although blood autoantibodies were initially associated with autoimmune diseases, multiple evidence have been accumulated showing their presence in many types of cancer. This has opened their use in clinics, since cancer autoantibodies might be useful for early detection, prognosis, and monitoring of cancer patients. In this review, we discuss the different techniques available for their discovery and validation. Additionally, we discuss here in detail those autoantibody panels verified in at least two different reports that should be more likely to be specific of each of the four most incident cancers. We also report the recent developed kits for breast and lung cancer detection mostly based on autoantibodies and the identification of novel therapeutic targets because of the screening of the cancer humoral immune response. Finally, we discuss unsolved issues that still need to be addressed for the implementation of cancer autoantibodies in clinical routine for cancer diagnosis, prognosis, and/or monitoring.engAttribution-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nd/4.0/journal articlehttps://doi.org/10.3389/fimmu.2024.1455602open access543humoral immune responseautoantibodiescancer autoantibodiescolorectal cancerbreast cancerlung cancerprostate cancerproteomicsCiencias2301 Química Analítica