García Culebras, AliciaCuartero Desviat, María IsabelPeña Martínez, Carolina BelénMoraga Yébenes, AnaVázquez Reyes, SandraDe Castro Millán, Francisco JavierCortes Canteli, MartaLizasoaín Hernández, IgnacioMoro Sánchez, María Ángeles2024-04-232024-04-232023-07-07García-Culebras A, Cuartero MI, Peña-Martínez C, Moraga A, Vázquez-Reyes S, de Castro-Millán FJ, Cortes-Canteli M, Lizasoain I, Moro MÁ. Myeloid cells in vascular dementia and Alzheimer's disease: Possible therapeutic targets? Br J Pharmacol. 2024 Mar;181(6):777-798. doi: 10.1111/bph.161590007-11881476-538110.1111/bph.16159https://hdl.handle.net/20.500.14352/103367Growing evidence supports the suggestion that the peripheral immune system plays a role in different pathologies associated with cognitive impairment, such as vascular dementia (VD) or Alzheimer's disease (AD). The aim of this review is to summarize, within the peripheral immune system, the implications of different types of myeloid cells in AD and VD, with a special focus on post-stroke cognitive impairment and dementia (PSCID). We will review the contributions of the myeloid lineage, from peripheral cells (neutrophils, platelets, monocytes and monocyte-derived macrophages) to central nervous system (CNS)-associated cells (perivascular macrophages and microglia). Finally, we will evaluate different potential strategies for pharmacological modulation of pathological processes mediated by myeloid cell subsets, with an emphasis on neutrophils, their interaction with platelets and the process of immunothrombosis that triggers neutrophil-dependent capillary stall and hypoperfusion, as possible effector mechanisms that may pave the way to novel therapeutic avenues to stop dementia, the epidemic of our time.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal articlehttps://doi.org/10.1111/bph.1615937282844https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16159open access616.894-053.9Alzheimer's diseaseNETsPSCIDMyeloid cellsNeutrophilsNeurociencias (Medicina)3205.07 Neurología