Marchena-Fernández, MiguelSánchez-Camacho Blázquez, CristinaMuñoz-Sáez, EmmaMacías-Castellano, AlbaCastro Soubriet, Fernando de2025-10-222025-10-222025-08-13Marchena-Fernández M, Sánchez-Camacho C, Muñoz-Sáez E, Macías-Castellano A, de Castro Soubriet F (2026). Sonic Hedgehog signaling in oligodendrogenesis, myelination, demyelinating diseases, and remyelination. Neural Regen Res. https://doi.org/10.4103/NRR.NRR-D-25-000051673-537410.4103/nrr.nrr-d-25-00005https://hdl.handle.net/20.500.14352/125270Supported by the Spanish Government (PID2022-143110OB-IOO), Merck Foundation (20234599), and Universidad Camilo José Cela (CEIDI_VI_08_06_XI_EMYDEM).The Hedgehog (HH) family includes Indian (IHH), Desert (DHH), and Sonic Hedgehog (SHH). HH signaling plays a crucial role in myelination and oligodendrocyte lineage development. SHH regulates the specification, proliferation, and migration of oligodendrocyte precursor cells (OPCs), being essential for myelin production and remyelination. The balance of SHH/SMO signaling affects both oligodendrocyte differentiation and demyelinating disease progression. Understanding this pathway may open new therapeutic strategies for multiple sclerosis and leukodystrophies.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal article1876-7958https://doi.org/10.4103/nrr.nrr-d-25-00005open access612.82Neurociencias (Biológicas)Fisiología animal (Biología)Biología celular (Biología)2407.04 Citología2411.11 Neurofisiología2490 Neurociencias3205.07 Neurología