Viso Beronda, AlmaFernández de la Pradilla Sainz de Aja, RobertoFlores Aguilar-Amat, AídaÁguila Sánchez, Miguel Ángel del2024-02-062024-02-062008-12-15Viso A, Fernández De La Pradilla R, Flores A, Del Águila MA. Highly diastereoselective Barbier allylation and iminium cyclization: a simple entry to bicyclic and tricyclic piperazinones. Tetrahedron 2008;64:11580–8. https://doi.org/10.1016/j.tet.2008.10.03410.1016/j.tet.2008.10.034https://hdl.handle.net/20.500.14352/99303Barbier allylation of 5,6-dihydropyrazin-2(1H)-ones leads to a single isomer of 3-allylpiperazin-2-ones in high yields. Further Pictet–Spengler–Grieco cyclization of 3-allylpiperazin-2-ones with aldehydes provides bicyclic and tricyclic piperazinones with high diastereoselectivity.engjournal articlehttps://doi.org/10.1016/j.tet.2008.10.034restricted accessPiperazinesDiastereoselective allylationIminium cyclizationQuímica orgánica (Química)2306 Química Orgánica