Cabal, BelénAlou Cervera, LuisCafini, FabioCouceiro, RamiroSevillano Fernández, DavidEsteban Tejeda, LeticiaGuitián, FranciscoTorrecillas, RamónMoya, José S.2024-07-152024-07-152014-06-25Cabal B, Alou L, Cafini F, Couceiro R, Sevillano D, Esteban-Tejeda L, Guitián F, Torrecillas R, Moya JS. A new biocompatible and antibacterial phosphate free glass-ceramic for medical applications. Sci Rep. 2014 Jun 25;4:5440.2045-232210.1038/srep05440https://hdl.handle.net/20.500.14352/106086In the attempt to find valid alternatives to classic antibiotics and in view of current limitations in the efficacy of antimicrobial-coated or loaded biomaterials, this work is focused on the development of a new glass-ceramic with antibacterial performance together with safe biocompatibility. This bactericidal glass-ceramic composed of combeite and nepheline crystals in a residual glassy matrix has been obtained using an antimicrobial soda-lime glass as a precursor. Its inhibitory effects on bacterial growth and biofilm formation were proved against five biofilm-producing reference strains. The biocompatibility tests by using mesenchymal stem cells derived from human bone indicate an excellent biocompatibility.engAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/journal articlehttps://doi.org/10.1038/srep05440https://www.nature.com/articles/srep05440open access611.02Microbiología médica2414 Microbiología