Barredo, Celia G.Gil-Marti, BeatrizDeveci, DeryaRomero, Nuria M.Martín Castro, Francisco Antonio2025-12-022025-12-022021-02Barredo CG, Gil-Marti B, Deveci D, Romero NM and Martin FA (2021) Timing the Juvenile-Adult Neurohormonal Transition: Functions and Evolution. Front. Endocrinol. 11:602285. doi: 10.3389/fendo.2020.6022851664-239210.3389/fendo.2020.602285https://hdl.handle.net/20.500.14352/128266This work was supported by MICINN (Grant number PGC2018-094630-B-I00 to FM), Comunidad de Madrid (CB was a recipient of “Ayuda de Garantía Juvenil para la contratación de investigadores predoctorales” fellowship, grant number PEJD-2019-PRE/BMD-15940), CSIC (BG-M was a recipient of a JAE intro fellowship, grant number JAEINT_19_00602), Inserm (ATIP-Avenir program to NR) and the French National Research Agency -ANR- (“Investments for the Future” programs LABEX SIGNALIFE ANR-11-LABX-0028 and IDEX UCAJedi ANR-15-IDEX-01 to NR). FM is a recipient of a RyC-2014-14961 contract. MEFP (CGB is a recipient of a FPU predoctoral fellowship, grant number FPU19/04449), UAM (BG-M is a recipient of a predoctoral fellowship, grant number SFPI/2020/00878).Puberty and metamorphosis are two major developmental transitions linked to the reproductive maturation. In mammals and vertebrates, the central brain acts as a gatekeeper, timing the developmental transition through the activation of a neuroendocrine circuitry. In addition to reproduction, these neuroendocrine axes and the sustaining genetic network play additional roles in metabolism, sleep and behavior. Although neurohormonal axes regulating juvenile-adult transition have been classically considered the result of convergent evolution (i.e., analogous) between mammals and insects, recent findings challenge this idea, suggesting that at least some neuroendocrine circuits might be present in the common bilaterian ancestor Urbilateria. The initial signaling pathways that trigger the transition in different species appear to be of a single evolutionary origin and, consequently, many of the resulting functions are conserved with a few other molecular players being co-opted during evolution.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/review articlehttps://doi.org/10.3389/fendo.2020.60228533643219https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2020.602285/fullopen access575.857.087.1591.3MetamorphosisPubertyUrbilateriaDrosophilaSleepJuvenile-adult transitionNeuro-hormonal regulationNeuroendocrine axisNeurociencias (Biológicas)EvoluciónFisiología animal (Biología)2490 Neurociencias2401.13 Fisiología Animal2409.91 Genética del desarrollo