Paris, J.L.Colilla Nieto, MontserratIzquierdo Barba, IsabelManzano García, MiguelVallet Regí, María Dulce Nombre2023-06-172023-06-1720170022-2461DOI 10.1007/s10853-017-0787-1https://hdl.handle.net/20.500.14352/17663RESEARCHER ID K-3719-2014 (Miguel Manzano García) ORCID 0000-0001-6238-6111 (Miguel Manzano García) RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí)Matrix degradation has a major impact on the release kinetics of drug delivery systems. Regarding ordered mesoporous silica materials for biomedical applications, their dissolution is an important parameter that should be taken into consideration. In this paper, we review the main factors that govern the mesoporous silica dissolution in physiological environments. We also provide the necessary knowledge to researchers in the area for tuning the dissolution rate of those matrices, so the degradation could be controlled and the material behaviour optimised.spajournal articlehttps://link.springer.com/open access54666615.46Silica dissolutionmatrix degradationdrug delivery systemsmesoporous silica nanoparticlesQuímica inorgánica (Farmacia)