Sebastián-Aldeanueva, ManuelLópez-Muñoz, FranciscoGuerra Guirao, José AntonioÁlamo, CecilioLópez-Muñoz, FranciscoSrinivasan, VenkataramanujamÁlamo, CecilioKato, Takahiro A.2024-01-182024-01-182016-11Sebastián-Aldeanueva, M., López-Muñoz, F., Guerra, J.A., Álamo, C. (2016). Antidepressant and Anticonvulsant Drugs as Adjuvant Analgesics in Chronic Pain. In: López-Muñoz, F., Srinivasan, V., de Berardis, D., Álamo, C., Kato, T. (eds) Melatonin, Neuroprotective Agents and Antidepressant Therapy. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2803-5_33978-81-322-2801-1978-81-322-2803-510.1007/978-81-322-2803-5_33https://hdl.handle.net/20.500.14352/93920Adjuvant analgesics are defined as drugs with a primary indication ther than pain that have analgesic properties in some painful conditions. The group includes numerous drugs in diverse classes. Although the widespread use of these drugs as first-line agents in chronic nonmalignant pain syndromes suggests that the term “adjuvant” is a misnomer, they usually are combined with a less-than-satisfactory opioid regimen when administered for cancer pain. Some adjuvant analgesics are useful in several painful conditions and are described as multipurpose adjuvant analgesics (antidepressants, corticosteroids, α2-adrenergic agonists, neuroleptics), whereas others are specific for neuropathic pain (anticonvulsants, local anesthetics, N-methyl-D-aspartate receptor antagonists), bone pain (calcitonin, bisphosphonates, radiopharmaceuticals), musculoskeletal pain (muscle relaxants), or pain from bowel obstruction (octreotide, anticholinergics). This article reviews the evidence supporting the use of two class of adjuvant analgesic for the treatment of chronic pain, antidepressant ans anticonvulsivants, and provides a comprehensive outline of dosing recommendations, side effects, and drug interactions.engbook parthttps://doi.org/10.1007/978-81-322-2803-5_33restricted accessNeuropathic PainAntiepileptic DrugAnalgesic EffectCancer PainTrigeminal NeuralgiaFarmacología (Medicina)Farmacología (Farmacia)3209 Farmacología