De Barrio, MFuentes, VTornero, PSánchez, IHerrero, TZubeldia Ortuño, José Manuel2025-01-222025-01-222008-01-08de Barrio M, Fuentes V, Tornero P, Sánchez I, Zubeldia J, Herrero T. Anaphylaxis to oral iron salts. desensitization protocol for tolerance induction. J Investig Allergol Clin Immunol. 2008;18(4):305-8. PMID: 18714540.https://hdl.handle.net/20.500.14352/115660Allergies to iron salts are seldom reported. We studied a patient with iron-deficiency anemia who had suffered anaphylactic reactions caused by oral iron salts. An allergy study was performed using single-blind, placebo-controlled oral challenge and skin tests with various iron salts as well as excipients in commercial formulations. Oral challenges were positive for 2 of the commercial formulations of iron salts. Intradermal tests with ferrous sulphate and ferrous lactate also showed positive results. All of the cutaneous tests using the excipients were negative. A desensitization protocol was designed which enabled us to readminister ferrous sulphate, although antihistamines were necessary to guarantee good tolerance to iron salts. We report a patient with allergy to iron salts, positive skin tests, and positive controlled challenge. We highlight the desensitization protocol designed to complete the therapeutic management of the anemia.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal articlehttps://www.jiaci.org/summary/vol18-issue4-num36218714540https://pubmed.ncbi.nlm.nih.gov/18714540/restricted access616-056.3Oral iron saltsAnaphylaxisDesensitizationAlergología3299 Otras Especialidades Médicas