Castellanos, NazarethBajo Bretón, RicardoCuesta Prieto, PabloVillacorta Atienza, José AntonioPaul Lapedriza, Nuria AscensiónGarcía Prieto, JuanDel Pozo, FernandoMaestu Unturbe, Fernando2024-01-312024-01-312011Castellanos NP, Bajo R, Cuesta P, Villacorta-Atienza JA, Paúl N, Garcia-Prieto J, del-Pozo F and Maestú F (2011) Alteration and reorganization of functional networks: a new perspective in brain injury study. Front. Hum. Neurosci. 5:90. doi: 10.3389/fnhum.2011.000901662-516110.3389/fnhum.2011.00090https://hdl.handle.net/20.500.14352/97428Received: 28 October 2010; Accepted: 11 August 2011; Published online: 21 September 2011. © 2011 Castellanos, Bajo, Cuesta, Villacorta-Atienza, Paúl, Garcia-Prieto, del-Pozo and Maestú. This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.Plasticity is the mechanism underlying the brain’s potential capability to compensate injury. Recently several studies have shown how functional connections among the brain areas are severely altered by brain injury and plasticity leading to a reorganization of the networks. This new approach studies the impact of brain injury by means of alteration of functional interactions. The concept of functional connectivity refers to the statistical interdependen- cies between physiological time series simultaneously recorded in various areas of the brain and it could be an essential tool for brain functional studies, being its deviation from healthy reference an indicator for damage. In this article, we review studies investigating functional connectivity changes after brain injury and subsequent recovery, providing an accessible introduction to common mathematical methods to infer functional connectivity, exploring their capabilities, future perspectives, and clinical uses in brain injury studies.engAlteration and reorganization of functional networks: a new perspective in brain injury studyjournal articlehttps://doi.org/10.3389/fnhum.2011.00090https://www.frontiersin.org/articles/10.3389/fnhum.2011.00090/fullopen access616.831612.82Brain injuryFunctional connectivityNeurophysiologyGraph theoryData classificationCienciasNeurociencias (Medicina)24 Ciencias de la Vida2490 Neurociencias