Félix Escalera, JudithDíaz del Cerro, EstefaníaGarrido, AntonioFuente Del Rey, María Mónica De La2024-12-052024-12-052024Félix, J., Díaz-Del Cerro, E., Garrido Tarrío, A., & De La Fuente, M. (2024). Characterization of a natural model of adult mice with different rate of aging. Mechanisms of Ageing and Development, 222. https://doi.org/10.1016/J.MAD.2024.1119910047-637410.1016/j.mad.2024.111991https://hdl.handle.net/20.500.14352/112162This research was funded by the Research Group UCM (910379).Aging is a heterogeneous process, so individuals of the same age may be aging at a different rate. A natural model of premature aging in mice have been proposed based on the poor response to the T-maze. Those that take longer to cross the intersection are known as Prematurely Aging Mice (PAM), while those that show an exceptional response are known as Exceptional non-PAM (E-NPAM), being the rest non-PAM (NPAM). Although many aspects of PAM and E-NPAM have been described, some aspects of their brain aging have not been studied. Similarly, it is known that PAM, NPAM and E-NPAM show a different rate of aging and longevity, but the differences between these three groups in behavior, immune function and oxidative-inflammatory state are unknown. The present study aims to deepen the study of brain aging in PAM and E-NPAM, and to study the differences in behavior, immunity, and oxidative-inflammatory state of peritoneal leukocytes between PAM, NPAM and E-NPAM. Results show deteriorated brains in PAM. Moreover, NPAM show an oxidative state similar to E-NPAM, an anxiety similar to PAM, and an intermediate immunity and lifespan between PAM and E-NPAM. In conclusion, immune function seems to be more associated with the longevity achieved.engAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/journal article1872-6216https://doi.org/10.1016/j.mad.2024.111991https://www.sciencedirect.com/science/article/pii/S0047637424000915?via%3Dihubopen access591.1591.5599.3257.017.6Premature agingBrainBehaviorImmune functionRedox stateLongevityFisiología animal (Biología)Comportamiento animalAnimales de laboratorio2401.13 Fisiología Animal2401.02 Comportamiento Animal2401.05 desarrollo Animal