Salazar Roa, MaríaLorente Pérez, María Del MarGarcía Taboada, ElenaGómez, Eduardo P.Dávila, DavidZúñiga García, PatriciaFlores Landeira, Juana MaríaRodríguez, AntonioHegedus, ZoltanMosen Ansorena, DavidAransay, Ana M.Hernandez Tiedra, SoniaLópez Valero, IsraelQuintanilla, MiguelSánchez García, María CristinaIovanna, Juan LDusetti, NelsonGuzmán Pastor, ManuelFrancis, Sheila E.Carracedo, ArkaitzKiss-Toth, EndreVelasco Díez, Guillermo2025-11-052025-11-052015-04Salazar, M., Lorente, M., García-Taboada, E., Gómez, E. P., Dávila, D., Zúñiga-García, P., … Velasco, G. (2015). TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling. Molecular & Cellular Oncology, 2(3). https://doi.org/10.4161/23723556.2014.98013410.4161/23723556.2014.980134https://hdl.handle.net/20.500.14352/125762In a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on the dysregulation of the phosphorylation of v-akt murine thymoma viral oncogene homolog (AKT) by the mammalian target of rapamycin complex 2 (mTORC2 complex), and the subsequent hyperphosphorylation and inactivation of the transcription factor Forkhead box O3 (FOXO3).engAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/journal article2372-3556http://dx.doi.org/10.4161/23723556.2014.980134https://www.tandfonline.com/doi/10.4161/23723556.2014.980134?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedopen access577.2576616-006.04Tribbles pseudokinasesAnimal models of cancerSkin carcinogenesisPTENProstate cancerBiología molecular (Biología)Biología celular (Biología)Oncología2415 Biología Molecular2407 Biología Celular3201.01 Oncología