León Martínez, RafaelBuendia Abaitua, IzaskunNavarro González De Mesa, ElisaMichalska Dziama, PatrycjaGameiro Ros, Isabel MarinaLópez Vivo, AliciaEgea Máiquez, Francisco JavierGarcía López, ManuelaGarcía García, Juan Antonio2024-02-092024-02-092015-10-15León Martínez R, Buendia Abaitua I, Navarro González De Mesa E, Michalska Dziama P, Gameiro Ros IM, López Vivo A, et al. Compounds derived from 3-Alkylamino-1H-indole acrylate, and the use thereof in the treatment of neurodegenerative diseases. 2015.https://hdl.handle.net/20.500.14352/100861The inventions relates to the methods for producing derivatives of 3-alkylamino-1-H indole acrylate (I) with transcription factor Nrf2-inducing activity, free radical scavenging activity and neuroprotective ability. The invention also relates to the use of derivatives according to the invention for the treatment of diseases, the pathogenesis of which involves oxidative stress, or diseases involving the deregulation of the activity of phase II genes activated by the factor Nrf2 such as Alzheimer´s disease, Parkinson´s disease, Huntington´s disease, multiple sclerosis, ictus or amyotrophic lateral sclerosis.engpatentUS2018/0105492restricted accessCiencias Biomédicas24 Ciencias de la Vida