Caballero, EsmeraldaAvendaño López, María CarmenMenéndez Ramos, José Carlos2026-03-022026-03-022000Avendaño C, Caballero E, Carlos Menéndez J. Synthesis of a Seco Analogue of Ardeemin. HETEROCYCLES 2000;53:1765. https://doi.org/10.3987/COM-00-8942.0385541410.3987/COM-00-8942.https://hdl.handle.net/20.500.14352/133651(1S,4S)-1-Indolylmethyl-4-methyl-2,4-dihydro-1H-pyrazino[2,1-b]-q uinazaline-3,6-dione, a seco analogue of ardeemin, was synthesized in six steps from L-tryptophan methyl ester via an N-protected 2,5-piperazinedione and using an aza-Wittig reaction for the preparation of the quinazoline system. The final acid-promoted deprotection required tuning of the reaction conditions in order to minimize a side reaction involving loss of the indolylmethyl side chain.engjournal articlehttps://doi.org/10.3987/COM-00-8942.metadata only accessQuímica orgánica (Química)2306 Química Orgánica