Olmos Buchelt, Yolanda2023-06-222023-06-222022-06-19Electronic: 2077-037510.3390/membranes12060633https://hdl.handle.net/20.500.14352/72486The ESCRT machinery is an evolutionarily conserved membrane remodeling complex that is used by the cell to perform reverse membrane scission in essential processes like protein degradation, cell division, and release of enveloped retroviruses. ESCRT-III, together with the AAA ATPase VPS4, harbors the main remodeling and scission function of the ESCRT machinery, whereas earlyacting ESCRTs mainly contribute to protein sorting and ESCRT-III recruitment through association with upstream targeting factors. Here, we review recent advances in our understanding of the molecular mechanisms that underlie membrane constriction and scission by ESCRT-III and describe the involvement of this machinery in the sealing and repairing of damaged cellular membranes, a key function to preserve cellular viability and organellar function.engAtribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/journal articlehttps://doi.org/10.3390/membranes12060633https://www.mdpi.com/2077-0375/12/6/633open access576.3577.2ESCRTMembrane scissionReverse topologyNuclear envelopeLysosomeMembrane sealingMembrane repairBiología celular (Biología)Biología molecular (Biología)2407 Biología Celular2415 Biología Molecular