Moreno-Quispe, Luz ASerrano Valle, JuliaVirto Ruiz, LeireSanz Alonso, MarianoRamírez Sanz, LucíaFernández-Castro, MónicaHernández Vallejo, GonzaloLópez-Pintor Muñoz, Rosa María2024-02-072024-02-072020-06-04Moreno-Quispe LA, Serrano J, Virto L, et al. Association of salivary inflammatory biomarkers with primary Sjögren's syndrome. J Oral Pathol Med. 2020;00:1–80904-251210.1111/jop.13070https://hdl.handle.net/20.500.14352/99868Background: Primary Sjogren’s syndrome (pSS) is an autoimmune disease that leads to salivary and lacrimal gland dysfunction. The adaptive immune response associated with T helper-2 lymphocytes appears to be altered in these patients. Therefore, the objective of this study was to determine the salivary levels of IL-6, 5 and 4 in patients with pSS when compared to a healthy control (HC) group. The secondary objectives were to study whether ILs levels in pSS patients were associated with salivary flow, patient-reported outcomes (PROMs) for xerostomia and oral health quality of life (OHIP-14), pSS classification criteria and presence of extraglandular manifestations. Methods: A case-control study was conducted in 36 patients with pSS and 35 HCs. Cytokine levels were measured using high-sensitivity multiplex map human immunoassays. Unstimulated and stimulated whole saliva were collected and patients filled out the questionnaires. The U-Mann-Whitney test, chi-squared and Spearman correlation test were used. Results: IL-6 was significantly higher in pSS patients than in HCs (p=0.0001). IL-6 was significantly higher in pSS patients with a positive salivary gland biopsy (p=0.04), whole stimulated saliva hyposalivation (p=0.02) and presence of musculoskeletal disorders (p=0.03). There was a non-significant positive correlation between IL-6 levels and PROMs for xerostomia (r=0.31; p=0.06) and OHIP-14 (r=0.07; p=0.68) in pSS patients. Levels of IL4 and IL5 were not detected in both pSS and HCs patients. Conclusions: Salivary IL-6 levels were significantly associated with pSS patients and therefore, it is hypothesized that this biomarker may be useful in the diagnosis and follow-up of this disease.engjournal article1600-0714https://onlinelibrary.wiley.com/doi/10.1111/jop.1307032538490open access616.311Oral Health Impact Profile-14primary Sjögren's syndromeSalivary biomarkerssalivary interleukinsVisual Analog Scale for xerostomiaCiencias BiomédicasOdontología (Odontología)24 Ciencias de la Vida3299 Otras Especialidades Médicas