Oblitas, Crhistian MarioGaleano Valle, FranciscoÁlvarez-Sala Walther, Luis AntonioDemelo Rodríguez, Pablo2024-02-062024-02-062022Oblitas CM, Galeano-Valle F, Cuenca-Carvajal C, Piqueras-Ruiz S, Alonso-Beato R, Alejandre-de-Oña Á, Carrascosa-Fernández P, Chacón Moreno AD, Parra-Virto A, Pérez Sanz MT, Abarca Casas L, Millán-Nohales C, Álvarez-Sala-Walther L, Demelo-Rodríguez P. Evaluation of simple laboratory parameters in SARS-CoV-2 infection: the role of ratios. Infect Dis (Lond). 2022 Dec;54(12):924-933. doi: 10.1080/23744235.2022.2131902. Epub 2022 Oct 12. PMID: 36221980.2374-423510.1080/23744235.2022.2131902https://hdl.handle.net/20.500.14352/99366Background: The real predictive prognostic capacity of cellular indices (or ratios) is unclear in SARS-CoV-2 infection. This study aimed to assess the prognostic role of previously well-known laboratory indices and new ones in hospitalized COVID-19 patients. Methods: A retrospective observational study from March to May 2022 evaluated laboratory indices on admission (neutrophil to lymphocyte-, derived neutrophil to lymphocyte-, platelet to lymphocyte-, CRP to lymphocyte-, CRP to albumin-, fibrinogen to lymphocyte-, d-dimer to lymphocyte-, ferritin to lymphocyte-, LDH to lymphocyte-, and IL-6 to lymphocyte ratios), in patients hospitalized due to SARS-CoV2 infection to determine the association with mortality, admission to an intensive care unit (ICU), need for non-invasive mechanical ventilation (NIMV), orotracheal intubation (OTI), or combined event at 30 days follow-up. Results: A total of 1113 COVID-19 patients were evaluated with a mean age of 64.1 ± 15.9 years (58.49% male), 166 (14.91%) patients died, 58 (5.21%) required ICU admission, 73 (6.56%) needed NIMV, 46 (4.23%) needed OTI, and 247 (22.19%) presented the combined event. All the ratios evaluated in this study showed statistical significance in the univariate analysis for mortality and combined event; however, only d-dimer to lymphocyte ratio >0.6 presented an independent association in the multivariate analysis for 30-day mortality (adjusted OR 2.32; p = .047) and 30-day combined event (adjusted OR 2.62; p = .014). Conclusions: Laboratory indices might be a potential biomarker for better prognosis stratification in hospitalized COVID-19 patients. d-Dimer to lymphocyte ratio presents an independent association for 30-day mortality and 30-day adverse outcomes in hospitalized COVID-19 patients.engjournal articlehttps://www.tandfonline.com/doi/abs/10.1080/23744235.2022.213190236221980https://pubmed.ncbi.nlm.nih.gov/36221980/restricted access612.017BiomarkersCOVID19SARS-CoV-2MortalityRatiosEnfermedades infecciosas2412 Inmunología