Campuzano Ruiz, SusanaBarderas Manchado, RodrigoMoreno-Casbas, María TeresaAlmeida, ÁngelesPingarrón Carrazón, José Manuel2024-06-252024-06-252024Campuzano, S., Barderas, R., Moreno-Casbas, M.T. et al. Pursuing precision in medicine and nutrition: the rise of electrochemical biosensing at the molecular level. Anal Bioanal Chem 416, 2151–2172 (2024). https://doi.org/10.1007/s00216-023-04805-51618-264210.1007/s00216-023-04805-5https://hdl.handle.net/20.500.14352/105232In the era that we seek personalization in material things, it is becoming increasingly clear that the individualized management of medicine and nutrition plays a key role in life expectancy and quality of life, allowing participation to some extent in our welfare and the use of societal resources in a rationale and equitable way. The implementation of precision medicine and nutrition are highly complex challenges which depend on the development of new technologies able to meet important requirements in terms of cost, simplicity, and versatility, and to determine both individually and simultaneously, almost in real time and with the required sensitivity and reliability, molecular markers of different omics levels in biofluids extracted, secreted (either naturally or stimulated), or circulating in the body. Relying on representative and pioneering examples, this review article critically discusses recent advances driving the position of electrochemical bioplatforms as one of the winning horses for the implementation of suitable tools for advanced diagnostics, therapy, and precision nutrition. In addition to a critical overview of the state of the art, including groundbreaking applications and challenges ahead, the article concludes with a personal vision of the imminent roadmap.engAttribution 4.0 Internationaljournal article1618-2650https://doi.org/10.1007/s00216-023-04805-5https://link.springer.com/article/10.1007/s00216-023-04805-5open access543577.1Precision medicine and therapyIndividualized nutritionElectrochemical biosensingMolecular markersQuímica analítica (Química)Bioquímica (Química)2301 Química Analítica2302 Bioquímica