Martínez-Carmona, MarinaGun´Ko, Yurii, K.Vallet Regí, María Dulce Nombre2023-06-172023-06-172018-12-151999-492310.3390/pharmaceutics10040279https://hdl.handle.net/20.500.14352/12956RESEARCHER ID N-3992-2014 (Marina Martínez Carmona) ORCID 0000-0002-2026-6266 (Marina Martínez Carmona) RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí)Mesoporous silica materials (MSM) have a great surface area and a high pore volume, meaning that they consequently have a large loading capacity, and have been demonstrated to be unique candidates for the treatment of different pathologies, including bacterial infection. In this text, we review the multiple ways of action in which MSM can be used to fight bacterial infection, including early detection, drug release, targeting bacteria or biofilm, antifouling surfaces, and adjuvant capacity. This review focus mainly on those that act as a drug delivery system, and therefore that have an essential characteristic, which is their great loading capacity. Since MSM have advantages in all stages of combatting bacterial infection; its prevention, detection and finally in its treatment, we can venture to talk about them as the “nightmare of bacteria”.engjournal articlehttps://www.mdpi.comhttp://www.ucm.es/valletregigroupopen accessmesoporous silicadrug deliverybacterial infectionbacterial biofilmbiofilmantibiotic resistancetargeting bacteriatargeting biofilmmultifunctional nanoparticlesMateriales3312 Tecnología de Materiales