Del Corral Núñez-Flores, TamaraFabero Garrido, RaúlPlaza Manzano, GustavoFernández de las Peñas, CésarNavarro Santana, Marcos JoséLópez De Uralde Villanueva, Ibai Julio2024-04-182024-04-182023-04-05del Corral, T.; Fabero-Garrido, R.; Plaza-Manzano, G.; Fernández-de-las-Peñas, C.; Navarro-Santana, M.J.; López-de-Uralde-Villanueva, I. Minimal Clinically Important Differences in Inspiratory Muscle Function Variables after a Respiratory Muscle Training Programme in Individuals with Long-Term Post-COVID-19 Symptoms. J. Clin. Med. 2023, 12, 2720. https://doi.org/10.3390/jcm120727202077-038310.3390/jcm12072720https://hdl.handle.net/20.500.14352/103222Objective: To establish the minimal clinically important difference (MCID) for inspiratory muscle strength (MIP) and endurance (IME) in individuals with long-term post-COVID-19 symptoms, as well as to ascertain which of the variables has a greater discriminatory capacity and to compare changes between individuals classified by the MCID. Design: Secondary analysis of randomised controlled trial of data from 42 individuals who performed an 8-week intervention of respiratory muscle training programme. Results: A change of at least 18 cmH2O and 22.1% of that predicted for MIP and 328.5s for IME represented the MCID. All variables showed acceptable discrimination between individuals who classified as “improved” and those classified as “stable/not improved” (area under the curve ≥0.73). MIP was the variable with the best discriminative ability when expressed as a percentage of prediction (Youden index, 0.67; sensitivity, 76.9%; specificity, 89.7%). Participants classified as “improved” had significantly greater improvements in quality of life and lung function compared with the participants classified as “stable/not improved”. Conclusion: In individuals with long-term post-COVID-19 symptoms, the inspiratory muscle function variables had an acceptable discriminative ability to assess the efficacy of a respiratory muscle training programme. MIP was the variable with the best discriminative ability, showing better overall performance when expressed as a percentage of prediction.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal articlehttps://doi.org/10.3390/jcm12072720open access615.8SARS-CoV-2minimal clinically important differenceinspiratory muscle trainingresponsivenessFisioterapia (Enfermería, Fisioterapia y Podología)Fisioterapia (Medicina)3213.11 Fisioterapia