Jaubert, OlivierCruz, GastãoBustin, AurélienSchneider, TorbenLavín Plaza, BegoñaKoken, PeterHajhosseiny, RezaDoneva, MariyaRueckert, DanielBotnar, RenéPrieto, Claudia2024-02-012024-02-012019Jaubert, Olivier, et al. «Water–Fat Dixon Cardiac Magnetic Resonance Fingerprinting». Magnetic Resonance in Medicine, vol. 83, n.o 6, junio de 2020, pp. 2107-23. https://doi.org/10.1002/mrm.28070.1522-259410.1002/mrm.28070https://hdl.handle.net/20.500.14352/97855Purpose: Cardiac magnetic resonance fingerprinting (cMRF) has been recently introduced to simultaneously provide T1, T2, and M0 maps. Here, we develop a 3-point Dixon-cMRF approach to enable simultaneous water specific T1, T2, and M0 mapping of the heart and fat fraction (FF) estimation in a single breath-hold scan. Methods: Dixon-cMRF is achieved by combining cMRF with several innovations that were previously introduced for other applications, including a 3-echo GRE acquisition with golden angle radial readout and a high-dimensional low-rank tensor constrained reconstruction to recover the highly undersampled time series images for each echo. Water–fat separation of the Dixon-cMRF time series is performed to allow for water- and fat-specific T1, T2, and M0 estimation, whereas FF estimation is extracted from the M0 maps. Dixon-cMRF was evaluated in a standardized T1–T2 phantom, in a water–fat phantom, and in healthy subjects in comparison to current clinical standards: MOLLI, SASHA, T2-GRASE, and 6-point Dixon proton density FF (PDFF) mapping. Results: Dixon-cMRF water T1 and T2 maps showed good agreement with reference T1 and T2 mapping techniques (R2 > 0.99 and maximum normalized RMSE ~5%) in a standardized phantom. Good agreement was also observed between Dixon-cMRF FF and reference PDFF (R2 > 0.99) and between Dixon-cMRF water T1 and T2 and water selective T1 and T2 maps (R2 > 0.99) in a water–fat phantom. In vivo DixoncMRF water T1 values were in good agreement with MOLLI and water T2 values were slightly underestimated when compared to T2-GRASE. Average myocardium septal T1 values were 1129 ± 38 ms, 1026 ± 28 ms, and 1045 ± 32 ms for SASHA, MOLLI, and the proposed water Dixon-cMRF. Average T2 values were 51.7 ± 2.2 ms and 42.8 ± 2.6 ms for T2-GRASE and water Dixon-cMRF, respectively. DixoncMRF FF maps showed good agreement with in vivo PDFF measurements (R2 > 0.98) and average FF in the septum was measured at 1.3%.engjournal article0740-3194https://doi.org/10.1002/mrm.28070open access577.1Bioquímica (Química)24 Ciencias de la Vida