Romero Martínez, Manuel AlejandroMorales García, José ÁngelRamos Alonso, Eva2025-01-292025-01-292022-08-02Romero A, Morales-García JA, Ramos E (2023) Melatonin: a multitasking indoleamine to modulate hippocampal neurogenesis. Neural Regen Res 18(3): 503-505. DOI: https://doi.org/10.4103/1673-5374.3501891673-537410.4103/1673-5374.350189https://hdl.handle.net/20.500.14352/116950Author contributions: All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication. AR conceived the idea and he has made substantial contributions to conception, design, supervision. ER and JAMG wrote-original draft preparation and critically revised the manuscript. All co-authors read and approved the final version of the manuscript.Neurodegeneration affects a large number of cell types including neurons, astrocytes or oligodendrocytes, and neural stem cells. Neural stem cells can generate new neuronal populations through proliferation, migration, and differentiation. This neurogenic potential may be a relevant factor to fight neurodegeneration and aging. In the last years, we can find growing evidence suggesting that melatonin may be a potential modulator of adult hippocampal neurogenesis. The lack of therapeutic strategies targeting neurogenesis led researchers to explore new molecules. Numerous preclinical studies with melatonin observed how melatonin can modulate and enhance molecular and signaling pathways involved in neurogenesis. We made a special focus on the connection between these modulation mechanisms and their implication in neurodegeneration, to summarize the current knowledge and highlight the therapeutic potential of melatonin.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal article1876-7958https://doi.org/10.4103/1673-5374.350189open access61Adult hippocampal neurogenesis; ; ; ; ; ; ; tAgingMelatoninNeural stem cellNeurodegenerationNeuroprotectionSignaling pathwayTherapeutic strategyNeurociencias (Medicina)32 Ciencias Médicas