Ramasubramanian, DarshanHernández Verdejo, José LuisLópez Alonso, José Manuel2025-02-262025-02-262025-02Ramasubramanian, D., Hernández-Verdejo, J.L. & López-Alonso, J.M. Influence of Contact Lens Parameters on Tear Film Dynamics. Bull Math Biol 87, 45 (2025). https://doi.org/10.1007/s11538-025-01425-110.1093/imammb/dqab010https://hdl.handle.net/20.500.14352/118339Esta publicación estará en acceso abierto a partir del 19 de febrero de 2026, tal y como marcan las políticas editoriales.This study employs a computational model to simulate the dynamics of tear fluid and tear film in conjunction with contact lens motion, examining the interplay between diverse contact lens characteristics—such as material, design, and dimensions—and key ocular factors like dry eye conditions, corneal size, and blink rate. These interactions are critical for customising lens fit to maximise wearer comfort. Utilising optical measurements from a single participant, the study integrates data on tear meniscus size, blink velocity, and palpebral fissure height with sixteen different contact lens parameters, including Young's modulus, thickness, diameter, and curvature. Correlation analyses were conducted to determine the impact of these parameters on the dynamics of the tear fluid and overall tear film. Results show that the diameter and Young's modulus of the contact lens significantly influence pre-lens tear film thickness, with robust, statistically significant correlations. In contrast, lens thickness and base curve showed minimal impact, as evidenced by weak and non-significant correlations. These findings underscore the critical roles of lens diameter and Young's modulus in enhancing the stability and distribution of tear fluid, thereby improving wearer comfort and advancing contact lens design.engjournal articlehttps://doi.org/10.1093/imammb/dqab010embargoed access617.7-089.243Contact lens designTear fluidTear film dynamicsCorrelation analysisWearer comfortÓptica y optometría32 Ciencias Médicas2209.15 Optometría