Avendaño López, María CarmenCaballero, EsmeraldaMendez-Vidal, CristinaQuesada, Ana R. deMenéndez Ramos, José Carlos2026-02-272026-02-2720061570-180810.2174/1570180067778055581875-628Xhttps://hdl.handle.net/20.500.14352/133494The MDR chemosensitising activity of several analogues of the ardeemins, including five derivatives of the ABCD fragment, nine derivatives of the complete hexacyclic framework and one seco analogue lacking the B ring was studied. The results obtained confirm that the pharmacophoric moiety of the ardeemins as MDR reversers is located at their DEF fragment, and suggest that the epimer of the ardeemins at the alanine stereocenter should be more active than the natural stereoisomer.engjournal articlehttps://doi.org/10.2174/157018006777805558metadata only access547Antitumour drug resistanceArdeeminGlycoprotein P-170MDRPharmacophoreQuímica orgánica (Química)2306 Química Orgánica