Arumugam, NatarajanAlmansour, Abdulrahman I.Suresh Kumar, RajuGovindasami, PeriyasamiAl-thamili, DhaifallahKrishnamoorthy, RajapandianPeriasamy, Vaiyapuri SubbarayanAlshatwi, AliMahalingam, S. M.Thangamani, ShankarMenéndez Ramos, José Carlos2023-06-172023-06-172018-05-051420-304910.3390/molecules23051094https://hdl.handle.net/20.500.14352/12717A series of spirooxindolopyrrolidine fused N -styrylpiperidone heterocyclic hybrids has been synthesized in excellent yield via a domino multicomponent protocol that involves one-pot three component 1,3-dipolar cycloaddition and concomitant enamine reactions performed in an inexpensive ionic liquid, namely 1-butyl-3-methylimidazolium bromide ([bmim]Br). Compounds thus synthesized were evaluated for their cytotoxicity against U-937 tumor cells. Interestingly; compounds 5i and 5m exhibited a better cytotoxicity than the anticancer drug bleomycin. In ddition; the effect of the synthesized compounds on the nuclear morphology of U937 FaDu cells revealed that treatment with compounds 5a–m led to their apoptotic cell death.engAtribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/journal articlehttps://doi.org/10.3390/molecules23051094https://www.mdpi.com/1420-3049/23/5/1094open access547domino reaction13-dipolar cycloadditionionic liquidscytotoxicity assaysmolecular dockingQuímica orgánica (Farmacia)