Villegas Díaz, María RocíoBaeza, AlejandroVallet Regí, María Dulce Nombre2023-06-172023-06-172018-04-251420-304910.3390/molecules23051008https://hdl.handle.net/20.500.14352/12066RESEARCHER ID V-7077-2017 (María Rocío Villegas Díaz) ORCID 0000-0002-1297-2355 (María Rocío Villegas Díaz) RESEARCHER ID K-8193-2014 (Alejandro Baeza) ORCID 0000-0002-2026-6266 (Alejandro Baeza) RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí)The use of therapeutic proteins plays a fundamental role in the treatment of numerous diseases. The low physico-chemical stability of proteins in physiological conditions put their function at risk in the human body until they reach their target. Moreover, several proteins are unable to cross the cell membrane. All these facts strongly hinder their therapeutic effect. Nanomedicine has emerged as a powerful tool which can provide solutions to solve these limitations and improve the efficacy of treatments based on protein administration. This review discusses the advantages and limitations of different types of strategies employed for protein delivery, such as PEGylation, transport within liposomes or inorganic nanoparticles or their in situ encapsulation.engjournal articlehttp://www.mdpi.com/1420-3049/23/5/1008https://www.ucm.es/valletregigroupopen access66546615.46Protein delivery systemPEGylationLiposomesNanoparticlesPolymeric nanocapsulesVprotein therapyMaterialesQuímica inorgánica (Farmacia)3312 Tecnología de Materiales