Carrasco, ElisaGómez de las Heras, ManuelGabandé-Rodríguez, EnriqueDesdín-Micó, GabrielaAranda Gómez, Juan FranciscoMittelbrunn, Maria2024-01-152024-01-152022Carrasco, E., Gómez de las Heras, M.M., Gabandé-Rodríguez, E. et al. The role of T cells in age-related diseases. Nat Rev Immunol 22, 97–111 (2022). https://doi.org/10.1038/s41577-021-00557-41474-173310.1038/ s41577-021-00557-4https://hdl.handle.net/20.500.14352/93165Age-related T cell dysfunction can lead to failure of immune tolerance mechanisms, resulting in aberrant T cell-driven cytokine and cytotoxic responses that ultimately cause tissue damage. In this Review, we discuss the role of T cells in the onset and progression of age-associated conditions, focusing on cardiovascular disorders, metabolic dysfunction, neuroinflammation and defective tissue repair and regeneration. We present different mechanisms by which T cells contribute to inflammageing and might act as modulators of age-associated diseases, including through enhanced pro-inflammatory and cytotoxic activity, defective clearance of senescent cells or regulation of the gut microbiota. Finally, we propose that ‘resetting’ immune system tolerance or targeting pathogenic T cells could open up new therapeutic opportunities to boost resilience to age-related diseases.engjournal article1474-1741https://doi.org/10.1038/s41577-021-00557-4restricted access577.27612.67T cellsAgingInmunologíaFisiología2412 Inmunología2411 Fisiología Humana