León Moreno, Lilia CarolinaReza Zaldívar, Edwin EstefanHernández Sapiéns, Mercedes AzucenaVillafaña Estarrón, ErikaGarcía Martín, MarinaOjeda Hernández, Doddy DeniseMatías-Guiu, Jordi A.Gómez Pinedo, UlisesMatías-Guiu Guía, JorgeCanales Aguirre, Alejandro Arturo2024-06-142024-06-142023-12-20León-Moreno LC, Reza-Zaldívar EE, Hernández-Sapiéns MA, Villafaña-Estarrón E, García-Martin M, Ojeda-Hernández DD, et al. Mesenchymal Stem Cell-Based Therapies in the Post-Acute Neurological COVID Syndrome: Current Landscape and Opportunities. Biomolecules 2023;14:8. https://doi.org/10.3390/biom14010008.10.3390/biom14010008https://hdl.handle.net/20.500.14352/1049642023 Descuento MDPIOne of the main concerns related to SARS-CoV-2 infection is the symptoms that could be developed by survivors, known as long COVID, a syndrome characterized by persistent symptoms beyond the acute phase of the infection. This syndrome has emerged as a complex and debilitating condition with a diverse range of manifestations affecting multiple organ systems. It is increasingly recognized for affecting the Central Nervous System, in which one of the most prevalent manifestations is cognitive impairment. The search for effective therapeutic interventions has led to growing interest in Mesenchymal Stem Cell (MSC)-based therapies due to their immunomodulatory, anti-inflammatory, and tissue regenerative properties. This review provides a comprehensive analysis of the current understanding and potential applications of MSC-based interventions in the context of post-acute neurological COVID-19 syndrome, exploring the underlying mechanisms by which MSCs exert their effects on neuroinflammation, neuroprotection, and neural tissue repair. Moreover, we discuss the challenges and considerations specific to employing MSC-based therapies, including optimal delivery methods, and functional treatment enhancements.engAttribution 4.0 Internationalhttps://creativecommons.org/licenses/by/4.0/journal articlehttps://doi.org/10.3390/biom14010008https://www.mdpi.com/2218-273X/14/1/8open access616.314Long COVIDMesenchymal stem cellsExosomesNeurological sequelaeCiencias Biomédicas32 Ciencias Médicas