Burgos Blasco, BárbaraGüemes Villahoz, NoemiSantiago García, José AntonioSantiago, José LuisFernández Vigo, José IgnacioEspino Paisán, LauraSarriá Ruiz, Beatriz IreneGarcía Feijoo, JuliánMartínez De La Casa Fernández-Borrella, José María2023-06-162023-06-162020Burgos Blasco, B., Güemes Villahoz, N., Santiago García, J. A. et al. «Hypercytokinemia in COVID-19: Tear Cytokine Profile in Hospitalized COVID-19 Patients». Experimental Eye Research, vol. 200, noviembre de 2020, p. 108253. DOI.org (Crossref), https://doi.org/10.1016/j.exer.2020.108253.0014-483510.1016/j.exer.2020.108253https://hdl.handle.net/20.500.14352/6672The aim of this study is to analyze the concentrations of cytokines in tear of hospitalized COVID-19 patients compared to healthy controls. Tear samples were obtained from 41 healthy controls and 62 COVID-19 patients. Twenty-seven cytokines were assessed: interleukin (IL)-1b, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL9, IL-10, IL-12, IL-13, IL-15, IL-17, eotaxin, fibroblast growth factor basic, granulocyte colony-stimulating factor (G-CSF), granulocyte-monocyte colony-stimulating factor (GM-CSF), interferon (IFN)-γ, interferon gamma-induced protein, monocyte chemo-attractant protein-1, macrophage inflammatory protein (MIP)-1a, MIP-1b, platelet-derived growth factor (PDGF), regulated on activation normal T cell expressed and secreted, tumor necrosis factor-α and vascular endothelial growth factor (VEGF).
In tear samples of COVID-19 patients, an increase in IL-9, IL-15, G-CSF, GM-CSF, IFN-γ, PDGF and VEGF was observed, along with a decrease in eotaxin compared to the control group (p < 0.05). A poor correlation between IL-6 levels in tear and blood was found. IL-1RA and GM-CSF were significantly lower in severe patients and those who needed treatment targeting the immune system (p < 0.05). Tear cytokine levels corroborate the inflammatory nature of SARS-CoV-2.engjournal articlehttps://doi.org/10.1016/j.exer.2020.108253https://www.sciencedirect.com/science/article/pii/S001448352030511Xhttp://hdl.handle.net/10261/220124open access616.98:578.834577.112.85612. 398. 145. 3617.7CytokineCOVIDTearInflammationEnfermedades infecciosasOftalmología3205.05 Enfermedades Infecciosas3201.09 Oftalmología