Gómez Gallego, MarSierra Rodríguez, Miguel ÁngelLorenzo Aparicio, María Del CarmenGarcía Álvarez, PabloCabeza de Marco, JavierGómez Gallego, María Del MarSierra Rodríguez, Miguel ÁngelDe Cola, Luisa2024-11-052024-11-052024-02-02Lorenzo-Aparicio, C.; García-Álvarez, P.; Cabeza, J. A.; Gómez-Gallego, M. ; Sierra, M. A. ChemistryEurope 2024, e20230006510.1002/ceur.202300065https://hdl.handle.net/20.500.14352/109969Supporting informationThis article reports the use of metal–metal interactions as a way to induce nucleobase stacking in a dinucleotide chain. We synthetized and study a series of C,N-cyclometallated platinum(II) binuclear complexes derived from 6-phenylpurine dinucleotide 1 as proligand, and β-diketonates, 2,2'-bipyridines and 1,10-phenanthroline as ancillary ligands. The X-ray diffraction analysis revealed that the diketonate derivatives 7 and 8 are chiral helixes sustained by Pt−Pt intramolecular interactions that allow the nucleobase stacking. The folded helical structures are maintained in solution, as demonstrated by the appearance of metal–metal-to-ligand charge-transfer (MMLCT) transitions in the UV-vis spectra. The influence of the ancillary ligand in the molecular structure was evidenced by the absence of bands derived from M−M interactions in the absorption spectra of 2,2’-bipyridine and and 1,10-phenanthroline derivatives 12–14. The existence of Pt−Pt in the complexes of this study can be also detected by electrochemistry.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal articlehttps://doi.org/10.1002/ceur.202300065https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ceur.202300065open access547Pt Pt interactionsNucleobase stackingBinuclear complexesChiral helixesCiencias23 Química