Zekri, KhaoulaZamorano León, José JavierSegura Fragoso, AntonioAlcaide, José R.Reche, CarmenAndrés Castillo, AlciraMartínez Martínez, Carlos HugoGiner, ManelJiménez García, RodrigoLópez De Andrés, Ana IsabelNavarro Cuéllar, CarlosGarcía Fernández, Miguel A.López Farre, Antonio José2023-06-222023-06-222022-01-25Zekri Nechar, K., Zamorano León, J. J., Segura Fragoso, A. et al. «Albumin Binds COVID-19 Spike 1 Subunit and Predicts In-Hospital Survival of Infected Patients—Possible Alteration by Glucose». Journal of Clinical Medicine, vol. 11, n.o 3, enero de 2022, p. 587. DOI.org (Crossref), https://doi.org/10.3390/jcm11030587.2077-038310.3390/jcm11030587https://hdl.handle.net/20.500.14352/71631(1) Background: This study aimed to analyze if the serum albumin levels of hospitalized SARS-CoV-2 (COVID-19) patients on admission could predict <30 days in-hospital all-cause mortality, and if glucose levels on admission affected this predictive ability. (2) Methods: A multicenter retrospective cohort of 1555 COVID-19-infected adult patients from public hospitals of the Madrid community were analyzed. (3) Results: Logistic regression analysis showed increased mortality for ages higher than 49 y. After adjusting for age, comorbidities and on-admission glucose levels, it was found that on-admission serum albumin ≥3.5 g/dL was significantly associated with reduced mortality (OR 0.48; 95%CI:0.36–0.62). There was an inverse concentration-dependent association between on-admission albumin levels and <30 days in-hospital all-cause mortality. However, when on-admission glucose levels were above 125 mg/dL, higher levels of serum albumin were needed to reach an association with survival. In vitro experiments showed that the spike protein S1 subunit of SARS-CoV-2 binds to native albumin. The binding ability of native albumin to the spike protein S1 subunit was decreased in the presence of an increasing concentration of glycated albumin. (4) Conclusions: On-admission serum albumin levels were inversely associated with <30 days in-hospital all-cause mortality. Native albumin binds the spike protein S1 subunit, suggesting that native albumin may act as a scavenger of the SARS-CoV-2 virus.engAtribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/journal articlehttps://doi.org/10.3390/jcm11030587https://www.mdpi.com/2077-0383/11/3/587/htmopen accessAlbuminCOVID-19GlucoseGlycated albuminIn-hospital mortalitySpike protein S1 subunitEndocrinologíaInmunología3205.02 Endocrinología2412 Inmunología