Rodrigues Díez, RaquelRodrígues Díez, RaúlRuiz Ortega, Marta2024-02-072024-02-072014-08-01Rodrigues-Díez R, Aroeira LS, Orejudo M, Bajo MA, Heffernan JJ, Rodrigues-Díez RR, Rayego-Mateos S, Ortiz A, Gonzalez-Mateo G, López-Cabrera M, Selgas R, Egido J, Ruiz-Ortega M. IL-17A is a novel player in dialysis-induced peritoneal damage. Kidney Int. 2014 Aug;86(2):303-15. doi: 10.1038/ki.2014.330085-253810.1038/ki.2014.3324552849https://hdl.handle.net/20.500.14352/99898The classical view of the immune system has changed by the discovery of novel T-helper (Th) subsets, including Th17 (IL-17A-producing cells). IL-17A participates in immune-mediated glomerulonephritis and more recently in inflammatory pathologies, including experimental renal injury. Peritoneal dialysis patients present chronic inflammation and Th1/Th2 imbalance, but the role of the Th17 response in peritoneal membrane damage has not been investigated. In peritoneal biopsies from dialyzed patients, IL-17A immunostaining was found mainly in inflammatory areas and was absent in the healthy peritoneum. IL-17A-expressing cells included lymphocytes (CD4+ and γδ), neutrophils, and mast cells. Elevated IL-17A effluent concentrations were found in long-term peritoneal dialysis patients. Studies in mice showed that repeated exposure to recombinant IL-17A caused peritoneal inflammation and fibrosis. Moreover, chronic exposure to dialysis fluids resulted in a peritoneal Th17 response, including elevated IL-17A gene and protein production, submesothelial cell infiltration of IL-17A-expressing cells, and upregulation of Th17 differentiation factors and cytokines. IL-17A neutralization diminished experimental peritoneal inflammation and fibrosis caused by chronic exposure to dialysis fluids in mice. Thus, IL-17A is a key player of peritoneum damage and it may be a good candidate for therapeutic intervention in peritoneal dialysis patients.engjournal articlehttps://www.kidney-international.org/article/S0085-2538(15)30286-6/fulltexthttps://pubmed.ncbi.nlm.nih.gov/24552849/restricted access612.017IL-17A/Th17 cellsPeritoneal dialysisRenal diseasesCiencias Biomédicas24 Ciencias de la Vida