Vicent, LourdesÁlvarez García, JesúsVazquez Garcia, RafaelGonzález Juanatey, José R.Rivera, MiguelSegovia, JavierPascual Figal, DomingoBover, RamónWorner, FernandoFernández Avilés, FranciscoAriza Sole, AlbertMartínez-Sellés D Oliveira Soares, Manuel2024-04-262024-04-262023-04-21Vicent, L.; Álvarez-García, J.; Vazquez-Garcia, R.; González-Juanatey, J.R.; Rivera, M.; Segovia, J.; Pascual-Figal, D.; Bover, R.; Worner, F.; Fernández-Avilés, F.; et al. Coronary Artery Disease and Prognosis of Heart Failure with Reduced Ejection Fraction. J. Clin. Med. 2023, 12, 3028. https://doi.org/ 10.3390/jcm120830282077-038310.3390/jcm12083028https://hdl.handle.net/20.500.14352/103560Our aim was to determine the prognostic impact of coronary artery disease (CAD) on heart failure with reduced ejection fraction (HFrEF) mortality and readmissions. From a prospective multicenter registry that included 1831 patients hospitalized due to heart failure, 583 had a left ventricular ejection fraction of <40%. In total, 266 patients (45.6%) had coronary artery disease as main etiology and 137 (23.5%) had idiopathic dilated cardiomyopathy (DCM), and they are the focus of this study. Significant differences were found in Charlson index (CAD 4.4 ± 2.8, idiopathic DCM 2.9 ± 2.4, p < 0.001), and in the number of previous hospitalizations (1.1 ± 1, 0.8 ± 1.2, respectively, p = 0.015). One-year mortality was similar in the two groups: idiopathic DCM (hazard ratio [HR] = 1), CAD (HR 1.50; 95% CI 0.83–2.70, p = 0.182). Mortality/readmissions were also comparable: CAD (HR 0.96; 95% CI 0.64–1.41, p = 0.81). Patients with idiopathic DCM had a higher probability of receiving a heart transplant than those with CAD (HR 4.6; 95% CI 1.4–13.4, p = 0.012). The prognosis of HFrEF is similar in patients with CAD etiology and in those with idiopathic DCM. Patients with idiopathic DCM were more prone to receive heart transplant.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal articlehttps://doi.org/10.3390/jcm12083028https://www.mdpi.com/2077-0383/12/8/3028open access616.127-005.8Cardiología3205.01 Cardiología