Sevillano Fernández, DavidAguilar, LorenzoAlou Cervera, LuisGimenez, María JoséTorrico, MarthaGonzález Hidalgo, NataliaCafini, FabioRelaño, María TeresaCoronel, PilarPrieto Prieto, José2024-07-242024-07-242008-03Sevillano D, Aguilar L, Alou L, Giménez M, Torrico M, González N, Cafini F, Relaño M, Coronel P, Prieto J 2008. Urine Bactericidal Activity against Escherichia coli Isolates Exhibiting Different Resistance Phenotypes/Genotypes in an In Vitro Pharmacodynamic Model Simulating Urine Concentrations Obtained after Oral Administration of a 400-Milligram Single Dose of Cefditoren-Pivoxil. Antimicrob Agents Chemother 52:. https://doi.org/10.1128/aac.01247-070066-480410.1128/aac.01247-07https://hdl.handle.net/20.500.14352/107129Activity of simulated cefditoren urinary concentrations was determined against seven Escherichia coli isolates. Bactericidal activity was obtained from 4 to 24 h against TEM-1 (penicillinase production/hyperproduction), TEM-34 (IRT-6), and TEM-116 (extended-spectrum beta-lactamase [ESBL]) and from 6 to 8 h against SHV/TEM-116 (ESBL) but never against SHV/TEM-1 (ESBL). Extension of bactericidal activity depended on the resistance genotype/phenotype tested.engjournal article1098-6596https://doi.org/10.1128/aac.01247-07https://journals.asm.org/doi/10.1128/aac.01247-07restricted access611.02Microbiología médica2414 Microbiología