González Serrano, JoséLópez-Pintor Muñoz, Rosa MaríaSerrano Valle, JuliaTorres García Denche, JesúsHernández Vallejo, GonzaloSanz Martín, Mariano2024-01-162024-01-162021González-Serrano J, López-Pintor RM, Serrano J, Torres J, Hernández G, Sanz M. Short-term efficacy of a gel containing propolis extract, nanovitamin C and nanovitamin E on peri-implant mucositis: A double-blind, randomized, clinical trial. J Periodont Res. 2021;56:897–906Short-term efficacy of a gel containing propolis extract, nanovitamin C and nanovitamin E on peri-implant mucositis. A double-blind, randomized, clinical trial. Journal of Periodontal Research 2021;. 56(5): 897 - 9060022-348410.1111/jre.12886https://hdl.handle.net/20.500.14352/93359Objective: To determine the efficacy of a gel containing propolis extract, nanovitamin C and nanovitamin E as adjuvant to mechanical debridement in the treatment of peri- implant mucositis (PM). Background: Propolis has anti-inflammatory and antibacterial effect that may im- prove peri-implant health. Methods: A randomized, double-blind study was performed on patients with at least one implant with PM. Participants received a professional prophylaxis and were in- structed to use either test or a control gel as toothpaste three times/day for 1 month. Clinical and microbiological parameters were evaluated. PM resolution was considered in absence of bleeding on probing (BOP). Data were analysed with Mann-Whitney U, Wilcoxon signed-rank and chi-square tests. Results: Forty-six patients participated (23 in each group). After treatment, 26.1% of test patients showed complete PM resolution versus 0% in control group (p = .02). Significant reductions were observed in plaque index (p = .03), BOP (p = .04) and prob- ing depths (p = .027) in test compared with control group. The reduction in Tannerella forsythia was statistically greater in test than in control group at 1-month follow-up (p = .02). Porphyromonas gingivalis was statistically reduced in test group from baseline to 1-month follow-up (p = .05). Conclusion: Test gel clinically improved PM and showed certain antimicrobial effect after 1 month in comparison with control group. Further long-term clinical trials are required to confirm these results.engAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/journal article1600-0765https://www.doi.org/10.1111/jre.1288633904601https://onlinelibrary.wiley.com/doi/full/10.1111/jre.12886restricted access616.314616.314-089.843AntioxidantsDental implantsPeri-implant mucositisPropolisCiencias BiomédicasOdontología (Odontología)Implantes dentales32 Ciencias Médicas3213 Cirugía3314 Tecnología Médica3213.13 Ortodoncia-Estomatología