Meyer, MatthiasFu, QiaomeiAximu Petri, AyinuerGlocke, IsabelleNickel, BirgitArsuaga Ferreras, Juan LuisMartínez Mendizábal, IgnacioGracia Téllez, AnaBermúdez de Castro, José MaríaCarbonell i Roura, EudaldPääbo, Svante2023-06-192023-06-1920140028-083610.1038/nature12788https://hdl.handle.net/20.500.14352/33740Excavations of a complex of caves in the Sierra de Atapuerca in northern Spain have unearthed hominin fossils that range in age from the early Pleistocene to the Holocene1. One of these sites, the ‘Sima de los Huesos’ (‘pit of bones’), has yielded the world’s largest assemblage of Middle Pleistocene hominin fossils2,3, onsisting of at least 28 individuals4 dated to over 300,000 years ago5. The skeletal remains share a number of morphological features with fossils classifieds Homo heidelbergensis and also display distinct neanderthalderived traits6–8. Here we determine an almost complete mitochondrial genome sequence of a hominin from Sima de los Huesos and show that it is closely related to the lineage leading to mitochondrial genomes of enisovans 9,10, an eastern Eurasian sister group to Neanderthals. Our results pave the way for DNA research on hominins from the Middle Pleistocene.engjournal articlehttp://dx.doi.org/10.1038/nature12788open access569.89Hominin fossilsHomo heidelbergensisMitochondrial genome sequenceSima de los huesosSpainPaleontología2416 Paleontología