Hernáiz Gómez-Degano, María JosefaPerona Requena, AlmudenaHoyos Vidal, María PilarFarrán, ÁngelesHernáiz Gómez-Degano, María Josefa2024-01-302024-01-302020Perona A, Hoyos P, Farrán Á, Hernáiz MJ. Current challenges and future perspectives in sustainable mechanochemical transformations of carbohydrates. Green Chem 2020;22:5559–83. https://doi.org/10.1039/D0GC00901F.1463-926210.1039/d0gc00901fhttps://hdl.handle.net/20.500.14352/96514The use of mechanochemistry in carbohydrate chemistry is currently a growing field in which many new developments are being made because of its potential application in green methodologies. Ball milling (BM) is a promising eco-friendly technique with excellent characteristics that allows mostly solvent-free, faster and energy-efficient reactions. In this context, we provide in this perspective review a critical summary and discussion of the main known synthetic methods for carbohydrates based on mechanochemistry. The combination of the promising properties of mechanochemistry with carbohydrate reactions can be advantageous for setting strategies aligned with the green chemistry principles.engjournal article1463-9270https://doi.org/10.1039/d0gc00901fhttps://pubs.rsc.org/en/content/articlelanding/2020/gc/d0gc00901frestricted accessSolvent-free synthesisIn-vitro degradationEnzymatic-hydrolisisMolecular-weightCatalytyc conversionStructural-propertiesEfficient synthesisClick chemistryGlycosyl azidesBall millsCienciasQuímicaQuímica orgánica (Química)Ciencias BiomédicasFarmaciaQuímica orgánica (Farmacia)23 Química2306 Química Orgánica2306.06 Química de Los Hidratos de Carbono3303 Ingeniería y Tecnología Químicas3303.05 Síntesis Química