Gisbert Garzarán, MiguelLozano Borregón, DanielVallet Regí, María Dulce Nombre2023-06-172023-06-172020-12-181999-492310.3390/ijms21249696https://hdl.handle.net/20.500.14352/7636RESEARCH ID  S-2443-2016  (Miguel Gisbert Garzarán) ORCID 0000-0001-9815-0354 (Miguel Gisbert Garzarán) RESEARCH ID B-5081-2017  (Daniel Lozano Borregón) ORCID 0000-0001-5902-9201 (Daniel Lozano Borregón) RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí)Current chemotherapy treatments lack of great selectivity towards tumoral cells, which 13 leads to nonspecific drug distribution and subsequent side effects. In this regard, the use of 14 nanoparticles able to encapsulate and release therapeutic agents has attracted growing attention. In 15 this sense, mesoporous silica nanoparticles (MSNs) have been widely employed as drug carriers 16 owing to their exquisite physico-chemical properties. Because MSNs present a surface full of silanol 17 groups, they can be easily functionalized to endow the nanoparticles with many different 18 functionalities, including the introduction of moieties with affinity for the cell membrane or relevant 19 compartments within the cell, thus increasing the efficacy of the treatments. This review manuscript 20 will provide the state-of-the-art on MSNs functionalized for targeting subcellular compartments, 21 focusing on the cytoplasm, the mitochondria and the nucleus.engAtribución 3.0 Españajournal articlehttps://doi.org/10.3390/ijms21249696https://www.ucm.es/valletregigrouphttps://www.mdpi.com/1422-0067/21/24/9696open accessMesoporous Silica NanoparticlesTargetingSubcellular targetingEndosomal escape23 MitochondriaNucleusNanomedicineStimuli-ResponsiveDrug delivery.Materiales3312 Tecnología de Materiales