Sanz Esporrin, JavierDi Raimondo, RiccardoVignoletti, FabioNúñez, JavierMuñoz, FernandoSanz Alonso, Mariano2023-06-172023-06-172021-06-170905-716110.1111/clr.13803https://hdl.handle.net/20.500.14352/8634CRUE-CSIC (Acuerdos Transformativos 2021)Objectives: The purpose of this experimental in vivo investigation was to evaluate the influence of modifying the implant surface by adding a monolayer of multiphosphonate molecules on the de novo bone formation and osseointegration. Material and Methods: The study was designed as an animal preclinical trial with intra-animal control and two healing periods, 2 and 8 weeks, to compare implants with an identical macro-design but with two different surfaces. Eight female Beagle dogs participated in the study. Control implants had a moderately rough surface combining sandblasting and acid etching; test implants had an additional monophosphonate layer covalently bonded to titanium. Histologic and radiographic (micro-CT) outcome variables were evaluated. Results: The first bone-to-implant contact (fBIC) was located more coronally for the test implants at the first (0.065 mm (95% CI = −0.82, 0.60)) and second healing milestones (0.17 mm (95% CI = −0.9, 0.55)). Most coronal BIC of the test implants displayed a higher percentage of osseointegration, +6.33% and +13.38% after 2 and 8 weeks, respectively; however, the differences were not statistically significant. The micro-CT examination did not show any BIC difference. Conclusions: The monophosphonate layer coating demonstrated clinical, histological, and radiographic results similar to the control surface.engAtribución-NoComercial-SinDerivadas 3.0 Españajournal articlehttps://doi.org/10.1111/clr.13803open accessAnimal modeldental implantshistologyimplant surfaceosseointegrationmonophosphonate layerwound chamberhistometric analysismicro-CTOdontología (Odontología)Implantes dentales3213.13 Ortodoncia-Estomatología3213.13 Ortodoncia-Estomatología