Yadav, MonikaGuzmán Aránguez, Ana IsabelPérez de Lara, María JesúsSingh, MandeepSingh, JogaPal Kaur, Indu2023-06-172023-06-172019-082352-340910.1016/j.dib.2019.104361https://hdl.handle.net/20.500.14352/13600Received 10 May 2019, Revised 19 July 2019, Accepted 29 July 2019, Available online 6 August 2019. Refers to: Bimatoprost loaded nanovesicular long-acting sub-conjunctival in-situ gelling implant: In vitro and in vivo evaluationIn vitro cytotoxicity and in vivo acute and 7 days repeat-dose ocular toxicity studies, were conducted in rabbits, in accordance with the Organisation for Economic Co-operation and Development (OECD) guidelines, for bimatoprost loaded nanovesicular aqueous dispersion (BMT-NV) and its in-situ gelling sub-conjunctival implant (BMT-NV-IM). For details on the preparation and evaluation of BMT-NV and its BMT-NV-IM for the control of glaucoma, please refer to ‘Bimatoprost loaded nanovesicular long-acting sub-conjunctival in-situ gelling implant: In vitro and in vivo evaluation’ (Yadav et al., 2019). The in vivo ocular toxicity was performed only after confirming dermal safety, as required by OECD. Histological evaluation of various ocular tissues, following sub-conjunctival implantation with BMT-NV-IM, was done for ocular tolerance studies.engAtribución 3.0 EspañaSafety data on in situ gelling bimatoprost loaded nanovesicular formulationsjournal articlehttps://doi.org/10.1016/j.dib.2019.104361https://www.sciencedirect.com/science/article/pii/S2352340919307152?via%3Dihub#!https://www.ncbi.nlm.nih.gov/pubmed/31485469open access617.7-007.681615.9CytotoxicityOcular toxicityIn situ gellingAcyte and repeat dose toxicitySub-conjunctival implantsCell linesOftalmologíaMedicamentos3201.09 Oftalmología