Martínez De La Casa Fernández-Borrella, José MaríaRayward, OSaenz Frances, FSantos Bueso, Enrique MiguelMéndez Hernández, Carmen DoraHerrero Vanrell, María Del RocíoGarcía Feijoo, JuliánGarcía Sánchez, Julián2024-08-022024-08-022012-05-04Martinez-de-la-Casa, J., Rayward, O., Saenz-Frances, F. et al. Effects of corneal thickness on the intraocular penetration of travoprost 0.004%. Eye 26, 972–975 (2012). https://doi.org/10.1038/eye.2012.7410.1038/EYE.2012.74https://hdl.handle.net/20.500.14352/107356Purpose: To determine whether the intraocular penetration of travoprost 0.004% is affected by central corneal thickness. Methods: Sixty-four patients who were scheduled for cataract surgery without any other ophthalmologic pathology of significance were enroled in this study. At 120 min before surgery, one drop of travoprost 0.004% was instilled in the eye to be operated on. At the start of surgery, a sample of aqueous humour was extracted to subsequently determine its AL-5848 concentration. These concentrations were compared among three groups of patients established according to central corneal thickness measurements obtained by ultrasound pachymetry. Results: Mean AL-5848 concentrations were 3.27±2.03 ng/ml in Group I (CCT<511 microns), 3.27±2.44 ng/ml in Group II (CCT≥511 and ≤574 microns), and 2.73±2.15 ng/ml in Group III (CCT>574 microns), indicating no significant differences among the groups. Conclusions: We were unable to demonstrate the greater or lesser penetration of travoprost depending on corneal thickness, which could explain differences in patient responses to this drug. © 2012 Macmillan Publishers Limited All rights reserved.engjournal articlehttps://doi.org/10.1038/EYE.2012.74https://www.nature.com/articles/eye201274restricted access617.7Oftalmología3201.09 Oftalmología